The Future of Molecular Target Discovery Through Simulation
The discovery of a new drug begins long before researchers test a promising molecule. First, they need to answer an essential question: where should the drug act? The answer may lie in a protein, enzyme, receptor, or another structure involved in a biological process. These structures can serve as molecular targets. Finding a suitable target, […]
O futuro da descoberta de alvos moleculares via simulação
A descoberta de um novo fármaco começa muito antes dos testes com uma molécula candidata. Primeiro, os pesquisadores precisam responder a uma pergunta essencial: onde o medicamento deve agir? A resposta pode estar em uma proteína, enzima, receptor ou outra estrutura ligada a um processo biológico. Essas estruturas podem atuar como alvos moleculares. Encontrar um […]
Nitrosamines and the Pharmaceutical Industry
Nitrosamines and Their Implications Nitrosamines are substances that raise concern due to their potential toxicity. They are formed by the bond between a nitroso group (-N=O) and a functional amine group (>N-) and can be found in various products, such as food and water. History and Research Since the 1950s, when Magee & Barnes discovered […]
Brazilian Medicines: History and Development
One of the first Brazilian medicines is Tríaga Brasilica and had its origins in the colonial period. It is a recipe based on plants, animals and other substances, such as minerals and oils, classified as a “panacea” for its ability to treat various diseases. Undeniably, it is an adaptation of the European Triaga Magna, recorded […]
The challenges of computational chemistry in industry
Computational chemistry has gained prominence in the industry due to technological advances and the encouragement of the use of alternative methods, replacing the use of animals. Despite being an innovation that has been present for over 50 years, acceptance by regulatory agencies is still slow, especially in Brazil. Factors Contributing to Slow Development: High Computational […]
Qualification of Impurities and Degradation Products
The qualification of impurities and degradation products is a crucial process to ensure the biological safety of consumed medicines. To this end, this process uses scientific tools and technical data in order to validate that the health risk related to the use of a specific substance is insignificant. Importance of Qualification The importance of this […]
Drug Development: The Role of In Silico Techniques
Drug development goes through several stages, from pre-clinical studies to clinical studies. In the in silico phase, it focuses on the beginning of pre-clinical research, before animal testing, with the aim of reducing costs and minimizing the use of animals in the laboratory. Furthermore, with the advancement of computational techniques, a significant possibility of savings […]
Inovação no P&D Farmacêutico com Análises Computacionais
A busca por novos compostos terapêuticos — sejam fármacos, nutracêuticos ou cosméticos — exige, cada vez mais, precisão, agilidade e segurança. Nesse cenário competitivo, as análises computacionais aplicadas ao desenvolvimento de medicamentos estão ganhando destaque como soluções tecnológicas indispensáveis no setor de Pesquisa e Desenvolvimento (P&D). Ao adotar modelos preditivos baseados em dados, torna-se possível […]
Innovation in Pharmaceutical R&D Through Computational Analysis
The race to discover new therapeutic compounds — whether drugs, nutraceuticals, or cosmetics — increasingly demands precision, speed, and safety. In this competitive landscape, computational analysis applied to drug development is emerging as an indispensable technological solution within Research and Development (R&D). By leveraging data-driven predictive models, it becomes possible to anticipate critical molecular properties […]
Quality Control in the Pharmaceutical Sector
Agencies strictly control the global pharmaceutical sector, establishing and monitoring guidelines to ensure the safety and quality of products, both those sold and those in the approval process. Additionally, these agencies play a crucial role in the ongoing oversight of manufacturing practices, thereby ensuring that standards are maintained at all stages of the product lifecycle. […]
