O Futuro da Toxicologia Preditiva: a Revolução da Próxima Década
Atualmente, a toxicologia preditiva — situada na intersecção entre biologia, ciência de dados e Inteligência Artificial (IA) — deixou de ser apenas uma promessa científica. De fato, ela já se consolidou como um dos principais pilares da segurança química moderna. Nos próximos dez anos, entretanto, não veremos apenas sua expansão, mas sim uma transformação profunda […]
The Future of Predictive Toxicology: The Next-Decade Revolution
Currently, predictive toxicology—positioned at the strategic intersection of biology, data science, and Artificial Intelligence (AI)—has evolved from a promising concept into a cornerstone of modern chemical safety. Over the next decade, however, the field will not merely expand; instead, it will fundamentally transform how risks are assessed and how molecules are prioritized, from early discovery […]
The challenges of computational chemistry in industry
Computational chemistry has gained prominence in the industry due to technological advances and the encouragement of the use of alternative methods, replacing the use of animals. Despite being an innovation that has been present for over 50 years, acceptance by regulatory agencies is still slow, especially in Brazil. Factors Contributing to Slow Development: High Computational […]
Pharmacokinetic and toxicological prediction: an essential step in R&D
Pharmacokinetic and toxicological prediction represents a strategic stage in the development of pharmaceuticals, cosmetics, and biotechnological products. According to the Tufts Center for the Study of Drug Development, the average cost to bring a new drug to market exceeds $2.6 billion. This process can take over 10 years, and despite all the investment, many projects […]
Previsão farmacocinética e toxicológica: etapa essencial no P&D
A previsão farmacocinética e toxicológica representa uma etapa estratégica no desenvolvimento de medicamentos, cosméticos e produtos biotecnológicos. Segundo o Tufts Center for the Study of Drug Development, o custo médio para lançar um novo fármaco no mercado ultrapassa US$ 2,6 bilhões. Esse processo pode durar mais de 10 anos e, apesar de todo o investimento, […]
Qualification of Impurities and Degradation Products
The qualification of impurities and degradation products is a crucial process to ensure the biological safety of consumed medicines. To this end, this process uses scientific tools and technical data in order to validate that the health risk related to the use of a specific substance is insignificant. Importance of Qualification The importance of this […]
Drug Development: The Role of In Silico Techniques
Drug development goes through several stages, from pre-clinical studies to clinical studies. In the in silico phase, it focuses on the beginning of pre-clinical research, before animal testing, with the aim of reducing costs and minimizing the use of animals in the laboratory. Furthermore, with the advancement of computational techniques, a significant possibility of savings […]
Innovation in Pharmaceutical R&D Through Computational Analysis
The race to discover new therapeutic compounds — whether drugs, nutraceuticals, or cosmetics — increasingly demands precision, speed, and safety. In this competitive landscape, computational analysis applied to drug development is emerging as an indispensable technological solution within Research and Development (R&D). By leveraging data-driven predictive models, it becomes possible to anticipate critical molecular properties […]
The Role of Computing in Advancing the Pharmaceutical Industry
Computing has played a crucial role in advancing research centers and industries, and the pharmaceutical industry has not been left behind. In this way, computer-aided drug planning was incorporated and improved to be used in the initial stages of development, helping to decide which molecules should be prioritized for financial investment. In Silico Methods and […]
Os desafios da química computacional na indústria
A química computacional tem ganhado destaque na indústria devido ao avanço tecnológico e ao incentivo ao uso de métodos alternativos, substituindo o uso de animais. Apesar de ser uma inovação presente há mais de 50 anos, a aceitação pelas agências regulatórias ainda é lenta, especialmente no Brasil. Fatores que Contribuem para o Desenvolvimento Lento: Alto […]
